Publications
Recent research publications:
CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23 Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open cazy_webscraper: local compilation and interrogation of comprehensive CAZyme datasets Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m1A22-tRNA methyltransferase TrmK Comprehensive evaluation of CAZyme prediction tools in fungal and bacterial species Kinetic and structural characterization of sialidases (Kdnases) from ascomycete fungal pathogens Sialidase and sialyltransferase inhibitors: targeting pathogenicity and disease The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence cazy_webscraper: for creating a local CAZy database An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity Analysis of the product streams obtained on butanosolv pretreatment of draff Dissecting the mechanism of (R)-3-hydroxybutyrate dehydrogenase by kinetic isotope effects, protein crystallography, and computational chemistry Exploitation of carbohydrate processing enzymes in biocatalysis Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction Metabolic inhibitors of O-GlcNAc transferase (OGT) that act in vivo implicate decreased O-GlcNAc levels in leptin-mediated nutrient sensing New irreversible α-ʟ-iduronidase inhibitors and activity-based probes Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level The enzymatic degradation of heparan sulfate Mechanism of the human nucleocytoplasmic hexosaminidase D Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars Advances in understanding glycosyltransferases from a structural perspective Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology Development of inhibitors as research tools for carbohydrate-processing enzymes How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity Insights into O-Linked N-Acetylglucosamine (O-GlcNAc) Processing and Dynamics through Kinetic Analysis of O-GlcNAc Transferase and O-GlcNAcase Activity on Protein Substrates Production of alpha-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase Structural snapshots of the reaction coordinate for O-GlcNAc transferase 6 ''-Azido-6 ''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses
Grüschow, S., McQuarrie, S., Ackermann, K., McMahon, S., Bode, BE., Gloster, TM. & White, MF., 13 Mar 2024, (E-pub ahead of print) In: Nucleic Acids Research. 15 p., gkae167.
Research output: Contribution to journal › Article › peer-review
McQuarrie, S., Athukoralage, J. S., McMahon, S. A., Graham, S., Ackermann, K., Bode, B. E., White, M. F. & Gloster, T. M., 27 Oct 2023, In: Nucleic Acids Research. 51, 19, p. 10590-10605 16 p.
Research output: Contribution to journal › Article › peer-review
Hobbs, E. E. M., Gloster, T. & Pritchard, L., 14 Aug 2023, In: Microbial Genomics. 9, 8, 23 p., 001086.
Research output: Contribution to journal › Article › peer-review
Sweeney, P., Galliford, A., Kumar, A., Raju, D., Krishna, N. B., Sutherland, E., Leo, C. J., Fisher, G., Lalitha, R., Muthuraj, L., Sigamani, G., Oehler, V., Synowsky, S. A., Shirran, S. L., Gloster, T., Melo Czekster, C., Kumar, P. & da Silva, R. G., May 2022, In: Journal of Biological Chemistry. 298, 6, 15 p., 102040.
Research output: Contribution to journal › Article › peer-review
Hobbs, E. E. M., Gloster, T., Chapman, S. & Pritchard, L., 26 Apr 2021.
Research output: Contribution to conference › Poster
Nejatie, A., Steves, E., Gauthier, N., Baker, J., Nesbitt, J., McMahon, S. A., Oehler, V., Thornton, N. J., Noyovitz, B., Khazaei, K., Byers, B. W., Zandberg, W. F., Gloster, T. M., Moore, M. M. & Bennet, A. J., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2632–2640 9 p.
Research output: Contribution to journal › Article › peer-review
Bowles, W. H. & Gloster, T., 29 Jul 2021, In: Frontiers in Molecular Biosciences. 8, 10 p., 705133.
Research output: Contribution to journal › Review article › peer-review
Zhu, W., McQuarrie, S. J., Gruschow, S., McMahon, S., Graham, S., Gloster, T. & White, M., 18 Mar 2021, In: Nucleic Acids Research. 49, 5, p. 2777–2789 13 p., gkab073.
Research output: Contribution to journal › Article › peer-review
Hobbs, E. E. M., Pritchard, L., Chapman, S. & Gloster, T., 26 Apr 2021.
Research output: Contribution to conference › Poster
Athukoralage, J. S., McMahon, S., Zhang, C., Gruschow, S., Graham, S., Krupovic, M., Whitaker, R., Gloster, T. & White, M., 23 Jan 2020, In: Nature. 577, 7791, p. 572-575 19 p.
Research output: Contribution to journal › Article › peer-review
Foltanyi, F., Hawkins, J. E., Panovic, I., Bird, E. J., Gloster, T., Lancefield, C. S. & Westwood, N. J., Oct 2020, In: Biomass and Bioenergy. 141, 105680.
Research output: Contribution to journal › Article › peer-review
G. Machado, T. F., Purg, M., McMahon, S., Read, B., Oehler, V., Åqvist, J., Gloster, T. & da Silva, R. G., 18 Dec 2020, In: ACS Catalysis. 10, 24, p. 15019–15032
Research output: Contribution to journal › Article › peer-review
Gloster, T. M., Apr 2020, In: Current Opinion in Chemical Biology. 55, p. 180-188 9 p.
Research output: Contribution to journal › Review article › peer-review
McMahon, S., Zhu, W., Graham, S., Rambo, R., White, M. & Gloster, T., 24 Jan 2020, In: Nature Communications. 11, 11 p., 500.
Research output: Contribution to journal › Article › peer-review
Athukoralage, J. S., McQuarrie, S. J., Gruschow, S., Graham, S., Gloster, T. & White, M., 20 Jul 2020, In: eLife. 9, 19 p., e57627.
Research output: Contribution to journal › Article › peer-review
Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In: Biochemistry. 57, 49, p. 6757-6761
Research output: Contribution to journal › Article › peer-review
Liu, T-W., Zandberg, W. F., Gloster, T. M., Deng, L., Murray, K. D., Shan, X. & Vocadlo, D. J., 19 Jun 2018, In: Angewandte Chemie International Edition. 57, 26, p. 7644-7648 5 p.
Research output: Contribution to journal › Article › peer-review
Artola, M., Kuo, C-L., McMahon, S. A., Oehler, V., Hansen, T., van der Lienden, M., He, X., van den Elst, H., Florea, B. I., Kermode, A. R., van der Marel, G. A., Gloster, T. M., Codée, J. D. C., Overkleeft, H. S. & Aerts, J. M. F. G., 26 Nov 2018, (E-pub ahead of print) In: Chemistry - A European Journal. Early View, 9 p.
Research output: Contribution to journal › Article › peer-review
Ren, W., Pengelly, R. J., Farren-Dai, M., Abadi, S. S. K., Oehler, V., Akintola, O., Draper, J., Meanwell, M., Chakladar, S., Świderek, K., Moliner, V., Britton, R., Gloster, T. & Bennet, A., 13 Aug 2018, In: Nature Communications. 9, 12 p., 3243.
Research output: Contribution to journal › Article › peer-review
Griffin, L. S. & Gloster, T. M., 1 Aug 2017, In: Protein & Peptide Letters. 24, 8, p. 710-722
Research output: Contribution to journal › Review article › peer-review
Alteen, M. G., Oehler, V., Nemčovičová, I., Wilson, I. B. H., Vacadlo, D. J. & Gloster, T. M., 17 May 2016, In: Biochemistry. 55, 19, p. 2753-2747
Research output: Contribution to journal › Article › peer-review
Adamson, C., Pengelly, R. J., Kazem Abadi, S. S., Chakladar, S., Draper, J., Britton, R., Gloster, T. M. & Bennet, A. J., 18 Nov 2016, In: Angewandte Chemie International Edition. 55, 48, p. 14978-14982
Research output: Contribution to journal › Article › peer-review
Gloster, T. M., Oct 2014, In: Current Opinion in Structural Biology. 28, p. 131-141 11 p.
Research output: Contribution to journal › Article › peer-review
He, X., Pierce, O., Haselhorst, T., Kolarich, D., Packer, N. H., Gloster, T., Vocadlo, D. J., Qian, Y., Brooks, D. & Kermode, A. R., Dec 2013, In: Plant Biotechnology Journal. 11, 9, p. 1034–1043
Research output: Contribution to journal › Article › peer-review
Stubbs, K. A., Bacik, J-P., Perley-Robertson, G. E., Whitworth, G. E., Gloster, T. M., Vocadlo, D. J. & Mark, B. L., Oct 2013, In: ChemBioChem. 14, 15, p. 1973-1981
Research output: Contribution to journal › Article › peer-review
Gloster, T. M. & Vocadlo, D. J., Aug 2012, In: Nature Chemical Biology. 8, 8, p. 683-694 12 p.
Research output: Contribution to journal › Review article › peer-review
Gloster, T. M., Oct 2012, In: Biochemical Society Transactions. 40, p. 913-928 16 p.
Research output: Contribution to journal › Article › peer-review
Cuskin, F., Flint, J. E., Gloster, T. M., Morland, C., Basle, A., Henrissat, B., Coutinho, P. M., Strazzulli, A., Solovyova, A. S., Davies, G. J. & Gilbert, H. J., 18 Dec 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20889-20894 6 p.
Research output: Contribution to journal › Article › peer-review
Shen, D. L., Gloster, T. M., Yuzwa, S. A. & Vocadlo, D. J., 4 May 2012, In: Journal of Biological Chemistry. 287, 19, p. 15395-15408 14 p.
Research output: Contribution to journal › Article › peer-review
He, X., Haselhorst, T., von Itzstein, M., Kolarich, D., Packer, N. H., Gloster, T. M., Vocadlo, D. J., Clarke, L. A., Qian, Y. & Kermode, A. R., Sept 2012, In: Nature Communications. 3, p. - 9 p., 1062.
Research output: Contribution to journal › Article › peer-review
Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J. & Davies, G. J., 17 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 781-786 6 p.
Research output: Contribution to journal › Article › peer-review
Lazarus, M. B., Jiang, J., Gloster, T. M., Zandberg, W. F., Whitworth, G. E., Vocadlo, D. J. & Walker, S., Dec 2012, In: Nature Chemical Biology. 8, 12, p. 966-968 3 p.
Research output: Contribution to journal › Article › peer-review
Mayer, A., Gloster, T. M., Chou, W. K., Vocadlo, D. J. & Tanner, M. E., 15 Feb 2011, In: Bioorganic and Medicinal Chemistry Letters. 21, 4, p. 1199-1201 3 p.
Research output: Contribution to journal › Article › peer-review
Gloster, T. M., Zandberg, W. F., Heinonen, J. E., Shen, D. L., Deng, L. & Vocadlo, D. J., Mar 2011, In: Nature Chemical Biology. 7, 3, p. 174-181 8 p.
Research output: Contribution to journal › Article › peer-review
He, Y., Bubb, A. K., Stubbs, K. A., Gloster, T. M. & Davies, G. J., Mar 2011, In: Amino Acids. 40, 3, p. 829-839 11 p.
Research output: Contribution to journal › Article › peer-review
Selected reviews:
- TM Gloster. Exploitation of carbohydrate processing enzymes in biocatalysis, 2020, Current Opinion in Chemical Biology 55, 180-188.
- LS Griffin, TM Gloster. The enzymatic degradation of heparan sulfate, 2017, Protein and peptide letters 24 (8), 710-722
- TM Gloster. Advances in understanding glycosyltransferases from a structural perspective, 2014, Curr Opin Struct Biol 28,131-41.
- TM Gloster. Development of inhibitors as research tools for carbohydrate-processing enzymes, 2012, Biochem Soc Trans, 40, 913-928.
- TM Gloster & DJ Vocadlo. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology, 2012, Nat Chem Biol, 8, 683-694.
- TM Gloster & GJ Davies. Glycosidase inhibition: assessing mimicry of the transition state, 2010, Org Biomol Chem, 8, 305-320.
Selected research publications that highlights the type of work and techniques that are being used in the Gloster group:
- TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng & DJ Vocadlo. Hijacking a biosynthetic pathway yields a potent glycosyltransferase inhibitor acting in cells, 2011, Nat Chem Biol, 7, 174-181.
- TM Gloster, JP Turkenburg, JR Potts, B Henrissat & GJ Davies. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora, 2008, Chem Biol, 15, 1058-1067.
- TM Gloster, P Meloncelli, RV Stick, DL Zechel, A Vasella & GJ Davies. Glycosidase inhibition: an assessment of the binding of eighteen putative transition-state mimics, 2007, J Am Chem Soc, 129, 2345-2354.
A full and up-to-date publication list for Tracey can be found on Google Scholar.